منابع مشابه
Chaperones and Glioma Immunotherapy
Molecular chaperones, also known as heat-shock proteins or HSPs, are a functionally conserved class of proteins whose primary function is to keep cellular proteins in their native conformation, under both physiological and stress conditions. In most cases these chaperones do not participate in the final mature structures that their ‘clients’ form. Apart from folding, chaperones play vital roles...
متن کاملImmunotherapy for malignant glioma
Malignant gliomas (MG) are the most common type of primary malignant brain tumor. Most patients diagnosed with glioblastoma (GBM), the most common and malignant glial tumor, die within 12-15 months. Moreover, conventional treatment, which includes surgery followed by radiation and chemotherapy, can be highly toxic by causing nonspecific damage to healthy brain and other tissues. The shortcoming...
متن کاملImmune-Checkpoint Blockade and Active Immunotherapy for Glioma
Cancer immunotherapy has made tremendous progress, including promising results in patients with malignant gliomas. Nonetheless, the immunological microenvironment of the brain and tumors arising therein is still believed to be suboptimal for sufficient antitumor immune responses for a variety of reasons, including the operation of "immune-checkpoint" mechanisms. While these mechanisms prevent a...
متن کاملMRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives
Pseudophenomena, that is, imaging alterations due to therapy rather than tumor evolution, have an important impact on the management of glioma patients and the results of clinical trials. RANO (response assessment in neurooncology) criteria, including conventional MRI (cMRI), addressed the issues of pseudoprogression after radiotherapy and concomitant chemotherapy and pseudoresponse during anti...
متن کاملUse of CD200 blockade inhibitor to enhance glioma immunotherapy
Background Utilizing tumors as a source of vaccine antigens in immunotherapy has demonstrated promising results. However, to date, researchers have failed to overcome the complex interplay between the tumor and its surrounding microenvironment resulting in T cell tolerance. The progression to a productive immune response involves a number of immunological checkpoints to be passed. Checkpoints s...
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ژورنال
عنوان ژورنال: Journal of Cancer Science & Therapy
سال: 2016
ISSN: 1948-5956
DOI: 10.4172/1948-5956.1000393